细胞穿膜肽的研究进展

孙春萌,沈雁,涂家生*

中国药学杂志 ›› 2013, Vol. 48 ›› Issue (14) : 1143-1146.

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中国药学杂志 ›› 2013, Vol. 48 ›› Issue (14) : 1143-1146. DOI: 10.11669/cpj.2013.14.002
综 述

细胞穿膜肽的研究进展

  • 孙春萌,沈雁,涂家生*
作者信息 +

Advance on the Research of Cell-Penetrating Peptides

  • SUN Chun-meng, SHEN Yan, TU Jia-sheng*
Author information +
文章历史 +

摘要

目的 综述细胞穿膜肽的研究进展。 方法 以近年来研究文献为基础,对细胞穿膜肽的结构特点、分类、内化机制、应用以及新的研究方向等进行综述。 结果 细胞穿膜肽(cell-penetrating peptides,CPPs)是一类由不多于30个氨基酸组成的小分子多肽,根据其氨基酸组成,可分为阳离子细胞穿膜肽和两亲性细胞穿膜肽。体内外研究表明,细胞穿膜肽能够介导多种载体的穿膜作用,无刺激性,并且在一定浓度范围内对宿主细胞无毒害作用。结论 细胞穿膜肽的作用机制仍需进行深入探讨,但其作为一种新型药物递送工具,具有广泛的应用前景。

Abstract

ObjectiveTo review the progress on cell-penetrating peptides(CPPs). Methods Based on the original researches in recent years, the structure properties, classification, internalization mechanism, application and novel research orientation of CPPs were introduced in the present paper. Results Cell-penetrating peptides(CPPs) consisted of 30 or less amino acids. CPPs, generally categorized as amphipathic or cationic depending on their sequences, are increasingly drawing attention as a non-invasive delivery technology for macromolecules. Delivery of a diverse set of cargoes has been attempted using different types of CPPs in vitro and in vivo. Additionally, the relative lack of toxicity and cell specificity has enabled its widespread use in preclinical models. This paper reviewed the studies on the structure properties, classification, internalization mechanism, application and novel research orientation of CPPs. Conclusion Although the internalization mechanism of CPPs will be studied deeply, CPPs, as a novel drug delivery tool, has promising application for the delivery of diverse drugs and cargoes.

关键词

细胞穿膜肽 / 结构特点 / 分类 / 内化机制

Key words

cell-penetrating peptide / structure property / classification / internalization mechanism

引用本文

导出引用
孙春萌,沈雁,涂家生*. 细胞穿膜肽的研究进展[J]. 中国药学杂志, 2013, 48(14): 1143-1146 https://doi.org/10.11669/cpj.2013.14.002
SUN Chun-meng, SHEN Yan, TU Jia-sheng*. Advance on the Research of Cell-Penetrating Peptides[J]. Chinese Pharmaceutical Journal, 2013, 48(14): 1143-1146 https://doi.org/10.11669/cpj.2013.14.002
中图分类号: R944   

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基金

基金项目:国家科技支撑计划资助项目(2008BAI55B03);国家“重大新药创制”科技重大专项资助项目( 2009ZX09310-004)

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